Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates "metabolic checkpoints" ...

Tumor Microenvironment and Metabolism

The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...].

CD47 in the tumor microenvironment limits cooperation between anti-tumor T cell immunity and radiation therapy

Tumor Microenvironment-Modulating Nanoparticles Boost Chemotherapy Efficacy and Anti-tumor Immunity

Virus-stimulated neutrophils in the tumor microenvironment enhance T cell-mediated anti-tumor immunity

The tumor microenvironment (TME) fosters tumors by attenuating anti-tumor immunity, reinforcing tumor cell survival and increasing angiogenesis. Among the constituents of the TME, here, we focused on tumor-associated neutrophils (TANs). First, we found that the combination of poly I:C and inactivated Sendai virus particles (hemagglutinating virus of Japan envelope; HVJ-E) synergistically suppre...